Kisspeptin-10

Kisspeptin-10 (KP-10, Metastin 45-54) is a 10-residue fragment of kisspeptin (Metastin) — a 54-residue peptide encoded by the KISS1 gene that is a master regulator of hypothalamic GnRH neurons and consequently of the reproductive endocrine axis. The 10-residue C-terminal fragment retains full KISS1R (the kisspeptin receptor) binding activity.

CAS 374683-28-0, molecular formula C₆₃H₈₃N₁₅O₁₃S, molecular weight 1302.55 g/mol. ChEMBL ID CHEMBL3422406.

Kisspeptin-10 binds the KISS1R (also called GPR54) receptor on GnRH neurons in the hypothalamus, triggering GnRH release and consequently downstream LH and FSH secretion from the anterior pituitary. The kisspeptin/KISS1R/GnRH axis is a principal regulator of reproductive function across mammals; loss-of-function mutations in KISS1 or KISS1R produce hypogonadotropic hypogonadism in humans.

Investigated in clinical and preclinical studies of reproductive-axis function, hypogonadotropic hypogonadism, and as a diagnostic probe for hypothalamic GnRH-neuron function. Kisspeptin-10 has also been investigated in infertility-related clinical research.

Supplied as a research-grade reference standard for laboratory use only. Not a licensed medicinal product in the United Kingdom and not approved by the MHRA for human or veterinary administration. Sale is restricted to researchers, institutions and laboratory professionals; the compound must be retained within research premises. End-user compliance with the Human Medicines Regulations 2012, the Misuse of Drugs Act 1971 (where applicable) and local institutional biosafety policy is the responsibility of the buyer.