Melanotan I 10mg

Melanotan I (afamelanotide; [Nle⁴-D-Phe⁷]-α-MSH) is a synthetic 13-residue analogue of alpha-melanocyte-stimulating hormone, studied in melanocortin-receptor and pigmentation research. It is supplied by NMChem as a research reference material.

The two substitutions

The name records exactly what was changed from the native sequence, and both changes are stabilising rather than incidental. Replacing methionine at position 4 with norleucine removes the sulfur atom that makes methionine the most oxidation-prone residue in a peptide — one of the main degradation routes described in storage and stability. Substituting D-phenylalanine at position 7 for the natural L-form introduces a residue that proteases do not readily cleave.

There is an analytical consequence worth noting: D- and L-amino acids have identical masses, so mass spectrometry cannot by itself confirm that position 7 carries the D-form. What mass spectrometry tells you covers stereochemistry among the four things a mass spectrum cannot resolve.

Melanotan I is a distinct molecule from Melanotan II, which is cyclic and shorter; the two are frequently conflated. NMChem also lists PT-141, a further melanocortin-system compound.

Presentation

10 mg lyophilised powder, SKU MT1-10.

Documentation

A Certificate of Analysis is produced per batch and is available on request against the lot number printed on the vial. Characterised by HPLC for purity and by mass spectrometry for identity. If you have not worked with this kind of report before, how to read a Certificate of Analysis walks through each section, and identity vs purity explains why the two headline numbers answer different questions.

Handling

Supplied lyophilised. Allow the sealed vial to reach room temperature before opening so atmospheric moisture does not condense onto cold glass, add solvent slowly down the vial wall rather than directly onto the cake, and dissolve without vortexing. Store the dry material at −20 °C, protected from light; aliquot reconstituted stock before freezing so no portion is thawed more than once. Storage and stability covers the degradation routes these steps are guarding against, and molar mass and solution concentration covers the arithmetic — including why the nominal vial weight is not the mass of peptide present. Practical procedure is in the reconstitution guide.

Research use only. Supplied for in-vitro research and laboratory use. Not for human or veterinary use, not a medicine, and not for food or cosmetic application. See the compliance page for the framework NMChem operates under.