SNAP-8
Acetyl Octapeptide-3 · synthetic SNARE-derived peptide
Identifier graph
Cross-references to canonical chemistry knowledge graphs. Each binding is the same identity used in PubMed-indexed literature.
- CAS Registry Number
- 868844-74-0 · CAS Common Chemistry
- InChIKey
-
KMACPCJUCHVVGP-FNRPHRCSSA-N - PubChem CID
- CID 76283482
- Wikidata
- Q27270653
- ChEMBL
- CHEMBL27308
- Molecular weight
- 1079.17 g/mol
- Peptide sequence
Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2- IUPAC name
- (4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
What is SNAP-8?
SNAP-8 (Acetyl Octapeptide-3) is a synthetic acetylated eight-residue peptide derived from the N-terminus of SNAP-25 — a SNARE-complex protein essential for synaptic-vesicle fusion and neurotransmitter release. The peptide sequence is Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂. Marketed under the cosmetic INCI name "Acetyl Octapeptide-3" or Leuphasyl, SNAP-8 is the subject of cosmetic-research applications focused on topical expression-line modulation.
CAS 868844-74-0, molecular weight 1079.17 g/mol. Wikidata QID Q27270653, ChEMBL ID CHEMBL27308.
Mechanism of action
SNAP-8 mimics the N-terminal sequence of SNAP-25 and acts as a competitive inhibitor of SNARE-complex assembly. By preventing SNAP-25 from associating with syntaxin and VAMP/ synaptobrevin at the presynaptic membrane, the peptide attenuates calcium-triggered vesicle fusion and therefore neurotransmitter release at the neuromuscular junction.
The mechanism is conceptually similar to botulinum-toxin type A (which cleaves SNAP-25) but with a fundamentally different mode of action — competitive binding rather than enzymatic cleavage.
Research context
Investigated in cosmetic-research applications focused on topical modulation of expression-line muscle activity. The compound is not used in injectable applications (where botulinum-toxin preparations dominate); rather, SNAP-8 is characterised in transdermal-delivery and topical-formulation research.
Analytical specifications
Every batch of SNAP-8 supplied by NMChem is characterised by reversed-phase HPLC for purity determination and by mass spectrometry for identity confirmation. Certificate of Analysis (COA) documents are issued per batch and made available on request.
Identity is confirmed by electrospray-ionisation mass spectrometry (ESI-MS); the observed mass falls within ±2 Da of the theoretical monoisotopic mass calculated from the residue sequence. Purity is determined by reversed-phase HPLC on a C18 column with a trifluoroacetic-acid-modified water/acetonitrile gradient and reported as the area-under-curve percentage of the main peak at 214 nm. NMChem specification is ≥99% main peak. Material ships as lyophilised powder and must be reconstituted in sterile water or bacteriostatic water immediately before use.
UK regulatory status
Supplied as a research-grade reference standard for laboratory use only. Not a licensed medicinal product in the United Kingdom and not approved by the MHRA for human or veterinary administration. Sale is restricted to researchers, institutions and laboratory professionals; the compound must be retained within research premises. End-user compliance with the Human Medicines Regulations 2012, the Misuse of Drugs Act 1971 (where applicable) and local institutional biosafety policy is the responsibility of the buyer.
Related compounds
Other research compounds in adjacent mechanism classes or commonly used alongside SNAP-8.
Frequently asked questions about SNAP-8
Is SNAP-8 the same as Acetyl Octapeptide-3?
How does SNAP-8 compare to botulinum toxin?
Get research-grade SNAP-8 from NMChem
UK supplier · HPLC and MS verified · Per-batch Certificate of Analysis · Tracked Royal Mail dispatch.