DSIP

Delta Sleep-Inducing Peptide (DSIP) is a 9-residue neuropeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly- Glu, originally isolated by Schoenenberger and Monnier in 1977 from rabbit cerebral venous blood during electrical stimulation of brain regions producing delta-wave (slow-wave) sleep.

CAS 62568-57-4, molecular formula C₃₅H₄₈N₁₀O₁₅, molecular weight 848.82 g/mol. Wikidata QID Q27294600, PubChem CID 68816, ChEMBL ID CHEMBL2104403.

DSIP's mechanism of action is incompletely characterised despite four decades of investigation. The peptide does not bind a known high-affinity receptor; rather, it appears to modulate multiple neurotransmitter systems including GABAergic, glutamatergic and serotonergic pathways. Some evidence supports interactions with the HPA axis (ACTH suppression) and stress-response modulation.

The published half-life is approximately 30 minutes.

Investigated in preclinical and small clinical studies of sleep regulation, stress response, and substance-withdrawal protocols. The literature is older and less developed than for newer research peptides; most foundational studies date to the 1980s and 1990s.

Supplied as a research-grade reference standard for laboratory use only. Not a licensed medicinal product in the United Kingdom and not approved by the MHRA for human or veterinary administration. Sale is restricted to researchers, institutions and laboratory professionals; the compound must be retained within research premises. End-user compliance with the Human Medicines Regulations 2012, the Misuse of Drugs Act 1971 (where applicable) and local institutional biosafety policy is the responsibility of the buyer.